Association Between Salivary Sirtuin-1 Levels and Periodontitis - PubMed
5 hours ago
- #salivary-biomarkers
- #SIRT-1
- #periodontitis
- Sirtuin-1 (SIRT-1) has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, and is involved in aging and age-related disorders.
- Previous studies with small sample sizes found no differences in salivary SIRT-1 levels between periodontitis patients and healthy subjects.
- This study aimed to analyze salivary SIRT-1 levels in a larger sample (144 subjects: 85 healthy, 59 with periodontitis).
- Salivary SIRT-1 concentrations < 1.2 ng/mL were independently associated with periodontitis (OR = 2.84; p = 0.04).
- SIRT-1 showed moderate diagnostic capability for periodontitis (AUC = 74%; p < 0.001) but is not sufficient alone.
- Low salivary SIRT-1 levels may be linked to periodontitis, but further research is needed to confirm findings.