Influenza vaccine-specific CD4+ T cell responses are impaired in older adults - PubMed
8 hours ago
- #influenza vaccine
- #ageing immunity
- #CD4 T cells
- Older adults have impaired influenza vaccine-specific CD4+ T cell responses, particularly against influenza A(H3N2).
- The study found reduced H3N2-specific CD4+ T-cell frequencies and polyfunctionality in individuals over 65 years old.
- These T-cell deficiencies correlated with lower H3N2 antibody titers, suggesting a link to weakened humoral immunity.
- Cytomegalovirus seropositivity was associated with diminished influenza-specific CD8+ T-cell responses in older adults.
- The findings highlight the need for vaccines that better enhance cellular immunity in the elderly, possibly through improved H3N2 antigen design.