Systematic profiling of human gut bacteria with cyclic di-AMP secretion to enhance anti-tumor immunity - PubMed
6 hours ago
- #gut microbiota
- #anti-tumor immunity
- #STING pathway
- Systematic profiling of human gut bacteria identifies high cyclic di-AMP producers.
- Cyclic di-AMP activates the STING pathway, enhancing anti-tumor immunity.
- 24 out of 51 gut bacterial species were identified as high cyclic di-AMP producers.
- Two food-grade probiotics, Limosilactobacillus fermentum DA785 and Lacticaseibacillus rhamnosus R7970, showed efficient cyclic di-AMP secretion.
- Supernatants from these probiotics upregulated STING pathway-related genes and IFN-β secretion in THP-1 cells.
- Oral administration of these strains suppressed tumor growth in a non-small cell lung cancer mouse model.
- The study suggests a novel microbiome-based strategy for cancer treatment using high cyclic di-AMP-producing probiotics.