Exploratory evaluation of CAP1 and ROCK2 as candidate blood biomarkers for vascular cognitive impairment - PubMed
6 hours ago
- #biomarkers
- #vascular cognitive impairment
- #proteomics
- Vascular cognitive impairment (VCI) is the second most common dementia etiology after Alzheimer's disease.
- Plasma biomarkers for VCI are insufficiently validated, prompting exploratory research.
- Proteomic and metabolomic analyses identified 871 differentially upregulated proteins in VCI patients compared to healthy controls.
- Key proteins investigated include YWHAZ, CLDN5, VCL, TPM4, TLN1, CAP1, ITGB3, GP1BB, and ROCK2.
- ELISA validation showed significantly higher levels of CAP1 and ROCK2 in VCI patients.
- CAP1 levels correlated with glycolysis-related metabolites, particularly lactate.
- Mendelian randomization analysis found no causal effect between plasma pQTL data and vascular dementia phenotypes.
- Findings suggest CAP1 and ROCK2 as potential biomarkers for VCI, warranting further investigation.