The effects of glucagon-like peptide-1 receptor agonists on fertility, contraception, and pregnancy: clinical perspectives - PubMed
5 hours ago
- #GLP-1 receptor agonists
- #pregnancy
- #fertility
- GLP-1 receptor agonists (GLP-1 RAs) improve fertility in obese women with PCOS by aiding weight loss and enhancing insulin sensitivity.
- Meta-analyses show higher spontaneous pregnancy rates in women with PCOS using GLP-1 RAs.
- Gastrointestinal side effects of GLP-1 RAs may reduce the absorption of oral contraceptives, suggesting non-oral methods may be more reliable.
- Animal studies suggest potential fetal risks, leading to recommendations for discontinuation before conception with specific washout periods.
- In men, GLP-1 RAs may indirectly improve reproductive parameters through metabolic benefits.
- Limited human data support the need for careful pregnancy planning and discontinuation of GLP-1 RAs before conception.
- GLP-1 RAs are effective in managing obesity-related infertility, especially in PCOS, but pregnancy safety data remain limited.