OptoTAT reveals microtubule acetylation as a rapid trigger for GEF-H1-mediated cell migration - PubMed
7 hours ago
- #GEF-H1
- #microtubule acetylation
- #cell migration
- Microtubule acetylation's role in cell migration was unclear due to lack of rapid manipulation tools.
- OptoTAT, a novel optogenetic actuator, was developed to induce microtubule acetylation quickly in live cells.
- Microtubule acetylation triggers GEF-H1 release from microtubules, enhancing actomyosin contractility and focal adhesion maturation.
- GEF-H1 is identified as a key responder to microtubule acetylation, linking actin and microtubule networks in cell motility.
- The study provides insights into the molecular mechanisms behind directional cell migration.