Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia - PubMed
4 hours ago
- #forebrain development
- #primary cilia
- #Togaram1
- The microtubule binding protein Togaram1 is essential for proper forebrain size, thickness, and morphology in mice.
- Loss of Togaram1 leads to structural defects like ventricular indentations, thin neuronal layers with gaps, and heterotopias.
- Togaram1 knockout results in increased and ectopic mitosis, elevated apoptosis, and shorter primary cilia in neural stem cells and neurons.
- The Shh signaling pathway is disrupted in Togaram1-deficient brains, linking ciliary dysfunction to forebrain malformations.
- Togaram1 is associated with Joubert Syndrome and microcephaly, highlighting its role in neurodevelopmental disorders.