Triple M overlap syndrome in the intensive care unit: differential diagnosis and management - PubMed
4 hours ago
- #Immune Checkpoint Inhibitors
- #Critical Care
- #Myocarditis
- Triple M overlap syndrome involves concurrent myasthenia gravis-like disease, inflammatory myositis, and myocarditis.
- It is a severe manifestation of immune checkpoint inhibitor (ICI) toxicity requiring intensive care.
- Diagnostic challenges include overlap with sepsis, pneumonia, and cardiopulmonary disease, with early tests often normal.
- Management includes discontinuing ICIs, early corticosteroids, and escalation to IVIG or plasma exchange for severe cases.
- Early multisystem evaluation with CK, troponins, ECG, and cardiac imaging is recommended alongside infection assessment.