Mesenchymal Stem Cell-Based Therapies Applied in Neurological Diseases: A Systematic Review - PubMed
5 hours ago
- #regenerative medicine
- #mesenchymal stem cells
- #neurodegenerative diseases
- Mesenchymal stem cells (MSCs) show potential for treating neurodegenerative diseases (NDs) due to their self-renewal and differentiation capabilities.
- MSCs and their derivatives demonstrate disease-modifying effects in preclinical models of Alzheimer's, Parkinson's, Huntington's, and ALS, improving behavioral outcomes and reducing neuroinflammation.
- Clinical studies confirm the safety and feasibility of MSC-based therapies, though efficacy remains modest and short-term, necessitating larger trials.
- Future approaches may integrate genetic engineering, preconditioning, and extracellular vesicle (EV) technology to enhance neuroregeneration.
- The review highlights the need for scalable, minimally invasive treatments to improve long-term outcomes in NDs.