Residual lipid risk in atherosclerotic cardiovascular disease - PubMed
5 days ago
- #Atherosclerosis
- #Lipid Risk
- #ASCVD
- Residual lipid risk persists in patients with or at risk of atherosclerotic cardiovascular disease (ASCVD) despite optimized LDL cholesterol levels.
- Non-LDL cholesterol fractions like remnant cholesterol, lipoprotein(a) [Lp(a)], apolipoprotein B (apoB), and non-HDL cholesterol contribute to residual ASCVD risk.
- Remnant cholesterol, Lp(a), and LDL cholesterol are independent lipoprotein species causing ASCVD through different mechanisms.
- Elevated remnant cholesterol and LDL cholesterol contribute to arterial wall cholesterol deposition, plaque development, and ASCVD endpoints.
- Triglyceride content in remnant particles may promote intimal inflammation and plaque rupture, independently contributing to atherogenesis.
- Lp(a) has pro-inflammatory properties and may contribute to atherosclerotic plaque development and more severe ASCVD outcomes.
- The review discusses therapeutic strategies targeting non-LDL lipid components to optimize lipid management beyond LDL cholesterol reduction.