ALS motor phenotypes: a revised 'OPM' classification - PubMed
7 hours ago
- #motor phenotypes
- #classification
- #ALS
- The 'ALS-OPM' classification is revised to define motor phenotypes in ALS for individualized care and therapeutic trial design.
- Onset (O1-4) categorizes first motor symptoms by region: head (O1), arm (O2d/p), trunk (O3r/a), or leg (O4d/p).
- Propagation (P1(n)) or absence (P0(n)) of motor symptoms is noted, with 'n' indicating months from onset to propagation/assessment.
- Motor dysfunction is classified by UMN and/or LMN involvement: balanced (M0), dominant/pure UMN (M1d/p), dominant/pure LMN (M2d/p), or dissociated (M3).
- The revised classification aims to standardize phenotype capture in clinical practice and trials.