Antidepressant Augmentation of Antipsychotic Treatment in Schizophrenia: A Narrative Review - PubMed
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- #antidepressants
- #schizophrenia
- Schizophrenia often has persistent negative symptoms, depressive features, and cognitive difficulties despite antipsychotic treatment.
- Antidepressants, particularly SSRIs and SNRIs, show modest improvements in negative symptoms, depressive symptoms, and overall functioning when combined with second-generation antipsychotics.
- Other antidepressant classes have inconsistent results due to pharmacological differences and study designs.
- Safety considerations include metabolic risk, drug interactions, and potential worsening of psychotic symptoms.
- Antidepressant augmentation may benefit selected patients with inadequate response to antipsychotic monotherapy.