Ferroptosis reshapes the tumor immune microenvironment: molecular mechanisms, immune regulation, and therapeutic synergistic strategies - PubMed
6 hours ago
- #cancer therapy
- #immune microenvironment
- #ferroptosis
- Ferroptosis is an iron-dependent, lipid peroxidation-driven form of programmed cell death.
- Core regulatory mechanisms include lipid peroxidation, antioxidant defense collapse (e.g., GPX4 axis), and iron/lipid metabolism remodeling.
- Interplay between ferroptosis and other cell death modalities (apoptosis, necroptosis) is discussed.
- Key signaling pathways (NRF2, p53, Hippo-YAP) play pivotal roles in ferroptosis regulation.
- Ferroptosis induction has potential in reversing drug resistance, inhibiting metastasis, and synergizing with immunotherapy.
- Strategies include direct induction (small-molecule inducers, nanodelivery) and combination with conventional/targeted therapies.
- Ferroptosis modulates immune cells (CD8+ T cells, macrophages) and reshapes the tumor immune microenvironment.
- Bidirectional interplay between ferroptosis and the immune microenvironment offers new avenues for combination immunotherapy.
- Challenges and future directions for clinical translation are outlined.