Synergistic Effects of SGLT2 Inhibitors and GLP-1R Agonists on Inflammation-Associated Oxidative Stress in Atrial Fibrillation - PubMed
5 hours ago
- #Oxidative Stress
- #Atrial Fibrillation
- #Combination Therapy
- The study examined the relationship between inflammation and the expression of SGLT2 and GLP-1R in right atrial appendages from cardiac surgery patients, including those with atrial fibrillation (AF).
- Inflamed right atrial appendages showed increased oxidative stress, fibrosis, and higher expression of SGLT2 and GLP-1R, which were more pronounced in AF patients.
- SGLT2 inhibitors and GLP-1R agonists reduced reactive oxygen species levels, with combination therapy being the most effective.
- The findings suggest combined SGLT2 inhibitor and GLP-1R agonist treatment could help prevent AF-related atrial remodeling by reducing oxidative stress.