Exploring the Treatment of Cinnamomum Cassia Leaf Extract in Ulcerative Colitis: Network Pharmacology and In Vitro Investigations - PubMed
5 hours ago
- #network pharmacology
- #Cinnamomum cassia
- #ulcerative colitis
- Cinnamomum cassia leaf extract (CCLE) was studied for its potential in treating ulcerative colitis (UC).
- Key components of CCLE were identified using UPLC-QTOF-MS.
- In vitro tests showed CCLE reduces nitric oxide (NO) and reactive oxygen species (ROS) production.
- CCLE inhibited macrophage migration, indicating anti-inflammatory effects.
- Network pharmacology and molecular docking identified key molecules targeted by CCLE, including TNF, TLR4, and STAT3.
- Therapeutic effects of CCLE on UC are linked to several signaling pathways like PI3K-Akt and NF-κB.
- Findings suggest CCLE could be developed further for UC treatment.