The Influence of Pharmacological Agents Used During General Anesthesia on the Intensity of Postoperative Pain and the Occurrence of Post-Anesthetic Delirium-A Scoping Review - PubMed
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- #delirium
- #anesthetics
- #postoperative pain
- Postoperative delirium is a fluctuating disturbance of attention and cognition in the post-anesthesia care unit.
- Anesthetic agents and postoperative pain intensity may influence the risk of delirium.
- Dexmedetomidine, remimazolam, and magnesium sulfate reduce the incidence and severity of postoperative delirium, especially in pediatric and elderly patients.
- Dexmedetomidine (2 µg/kg) improves postoperative analgesia and reduces agitation without prolonging recovery time.
- Propofol has rapid metabolism but its impact on cognitive function needs further investigation.
- Hydromorphone provides better postoperative pain control than sufentanil.
- Remimazolam reduces delirium incidence but does not affect the length of stay in the post-anesthesia care unit.
- Magnesium sulfate alleviates postoperative symptoms like pain and insomnia in adults.
- Ketamine does not consistently prevent delirium and may increase neuropsychiatric events.
- There is a lack of validated tools for pain assessment in delirious patients.