The impact of viral and host factors on the influenza A virus transmission bottleneck - PubMed
5 hours ago
- #Viral Genetics
- #Influenza A Virus
- #Transmission Bottleneck
- The transmission bottleneck restricts the number of unique influenza A virus (IAV) variants that pass between hosts, limiting viral diversity.
- A study of 56-60 household transmission pairs found a tight genetic bottleneck of approximately 1 virion (CI 1, 1), regardless of season, subtype, or host factors like vaccination status, age, or sex.
- This bottleneck appears intrinsic to IAV transmission, preventing onward spread of new mutations and maintaining genetic stability during household outbreaks.