Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes - PubMed
5 hours ago
- #lymphotoxin-β
- #type 1 diabetes
- #spatial transcriptomics
- Study explores inflammatory response in pancreas and pancreatic lymph nodes (pLNs) during type 1 diabetes (T1D) progression.
- Spatial transcriptomics (ST) used to profile non-diabetic (ND), at-risk autoantibody-positive (AAb+), and T1D donors.
- T1D pancreas shows global upregulation of inflammation-associated transcripts (REG family, C3, SOD2, OLFM4).
- T1D pLN exhibits significant upregulation of LTB within lymphoid follicles.
- Follicular B cells identified as primary source of LTB in pLN using subcellular-resolution ST.
- Increased LTB expression observed in lymphocytes near CCL19/CCL21-expressing endothelium in insulitic lesions.
- Findings highlight lymphotoxin-β and chemokine signatures in pancreatic lymphatics and insulitic lesions.
- Results may inform future therapeutic interventions for T1D.