Probable ceftriaxone-resistant neurosyphilis in an HIV-positive patient: A case report of clinical failure and response to doxycycline - PubMed
5 hours ago
- #Neurosyphilis
- #HIV
- #Ceftriaxone resistance
- A 63-year-old man with well-controlled HIV developed seizures and altered mental status due to neurosyphilis.
- Initial treatment with high-dose intravenous ceftriaxone (2 g twice daily for 10 days) failed to resolve neurological symptoms.
- Switching to intravenous doxycycline (100 mg twice daily) led to rapid clinical improvement within 72 hours.
- Follow-up tests confirmed complete resolution of inflammatory changes after a 28-day doxycycline course.
- This case highlights ceftriaxone resistance in HIV-associated neurosyphilis and doxycycline as a viable alternative.