Validating and updating the OHTS-EGPS model predicting 5-year glaucoma risk among patients with ocular hypertension using electronic medical records: a cohort study - PubMed
5 hours ago
- #risk-prediction
- #glaucoma
- #ocular-hypertension
- The study validated and updated the OHTS-EGPS model for predicting 5-year glaucoma risk in UK patients with ocular hypertension using electronic medical records.
- The updated model showed modest improvement with a pooled c-index of 0.67 compared to the original model's 0.61.
- Economic analysis suggested that using the risk predictor strategy is likely to be cost-effective, though it increases costs and quality-adjusted life-years.
- Patients with ocular hypertension and intraocular pressure of 22-23 mmHg had similar conversion risks to the rest of the cohort, making a treat-all strategy potentially not cost-effective.
- Patient preferences indicated a strong preference for hospital-based monitoring, though those with prior community optometrist experience preferred it.
- Limitations included insufficient data on ethnicity and ocular factors like optic disc anatomy.
- Future work should explore genetic factors, different eye care models, and ways to prevent late glaucoma presentation.