Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease - PubMed
2 months ago
- #Alzheimer's disease
- #sleep physiology
- #tau pathology
- Accelerated long-term forgetting (ALF) may be one of the earliest cognitive changes in Alzheimer's disease (AD).
- The study assessed ALF, sleep physiology, and AD neuropathology in 28 non-demented PSEN1 E280A mutation carriers and 24 healthy non-carriers.
- Non-demented carriers showed ALF despite intact short-term memory and isolated reduction in parietal sleep spindle (SS) power.
- Reduced parietal SS power was linked to both ALF and greater tau burden in the precuneus.
- ALF is among the earliest cognitive changes in preclinical autosomal-dominant AD (ADAD), with disrupted parietal SS power potentially linking early tau accumulation to ALF.