The Immune Cell Atlas of "Longevity Molecular Tag": Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms - PubMed
4 hours ago
- #centenarian
- #immunosenescence
- #scRNA-seq
- Immunosenescence is a critical aspect of aging, with centenarians serving as a model of 'healthy aging' due to their immune compensatory adaptation.
- The study used single-cell RNA sequencing and bulk transcriptomic data to identify immune cell subsets associated with longevity (Scissor+ and Scissor- cells).
- Scissor+ cells (NK cells, CD8+ T cells, γδ T cells) exhibit enhanced cytotoxic and immunomodulatory functions, while Scissor- cells (CD4+ T cells, B cells, DCs) are linked to inflammatory pathways.
- Trajectory analysis revealed differentiation pathways for NK, CD8+ T, CD4+ T, and B cells, with differentially expressed genes enriched in NF-κB signaling, T cell receptor signaling, and NK cell cytotoxicity.
- Five eQTL-colocalized events (e.g., rs3793537-GLIPR2/CD72/TLN1) were identified as associated with longevity.
- Centenarians achieve immune equilibrium by remodeling cytotoxic immune lineages and fine-tuning inflammatory responses, promoting health span and longevity.