A subphenotype of obesity with reduced enteroendocrine GLP-1 synthesis and enhanced tirzepatide response - PubMed
5 hours ago
- #GLP-1-synthesis
- #tirzepatide-response
- #obesity-subphenotype
- Identified a subphenotype of obesity with fast gastric emptying, low GLP-1 synthesis, and enhanced tirzepatide response.
- Cluster analysis revealed 26.9% of participants had discordant low GLP-1 despite fast gastric emptying and increased hunger.
- This subphenotype showed reduced mucosal expression of GLP-1 and PYY genes and greater weight loss on tirzepatide therapy.
- Higher plasma short-chain fatty acids observed in this group, but no significant differences in fecal microbiome.
- Findings support precision medicine approaches in obesity treatment based on individual physiological traits.