SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells - PubMed
4 hours ago
- #CAR T cell therapy
- #JAK-STAT signaling
- #SATB1
- SATB1 is a chromatin organizer essential for thymic Treg cell development and T helper cell induction.
- It regulates specific gene loci including GATA3 and cytokine loci such as IL-4 and IL-17.
- SATB1 ablation causes subset-specific gene signatures with broader effects on Treg cells, dysregulating cytokine and JAK-STAT signaling.
- SATB1 knockout reduces the suppressive capacity of human Treg cells but enhances tumor clearance by CD4 CAR T cells in a preclinical model.
- Modulating SATB1 could boost CAR T cell therapy efficiency by destabilizing Tregs and activating CD4 CAR T cells simultaneously.