Joint effects of contaminants of emerging concern (CECs) on sleep quality in Chinese elderly: A Bayesian kernel machine regression and quantile g-computation analysis - PubMed
5 hours ago
- #elderly health
- #CECs
- #sleep quality
- Study examines the joint effects of contaminants of emerging concern (CECs) on sleep quality in elderly Chinese population.
- 3096 seniors aged 60+ participated, with urine samples analyzed for 50 CECs and sleep quality assessed via Pittsburgh Sleep Quality Index (PSQI).
- Multivariable logistic analysis linked azithromycin, sulfamonomethoxine, lincosamides, and DEET to reduced sleep quality (ORs 1.17-1.38).
- Bayesian kernel machine regression (BKMR) showed combined association of five antibiotic categories and five other CECs with poor sleep quality.
- Quantile g-computation (Qgcomp) regression identified adverse combined effect of five antibiotic categories and five CECs on sleep quality (OR=1.21).
- DEET, tetracyclines, and acetaminophen had the highest contributions to poor sleep quality (weights 0.308, 0.229, and 0.220 respectively).
- Findings suggest public health interventions targeting environmental CECs and medication management are needed to protect elderly sleep quality.