PPT1 regulates mitochondrial redox by depalmitoylating PRDX3 - PubMed
5 hours ago
- #Depalmitoylation
- #Multiple myeloma
- #Mitochondrial redox homeostasis
- PPT1 regulates mitochondrial redox by depalmitoylating PRDX3 at cysteine C108.
- PPT1 inhibition increases mitochondrial reactive oxygen species (mtROS) and cytotoxicity in multiple myeloma (MM) cells.
- PPT1 suppression reduces xenograft tumor growth and elevates PRDX3 S-palmitoylation levels.
- PPT1-PRDX3 axis identified as a promising therapeutic target for MM.