Population and single-cell analyses reveal immune cell-specific expression profiles associated with Alzheimer's disease risk - PubMed
5 hours ago
- #Alzheimer's disease
- #genetics
- #immune system
- Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk.
- Mendelian randomization and colocalization analyses identified 13 genes associated with AD risk.
- Seven genes (BIN1, CTSW, CTSH, HLA-DRB1, TSTD1, PLEKHA1, SCIMP) increased AD risk, while six (EPHA1-AS1, FCER1G, FIBP, KAT8, STX4, HLA-DQA1) reduced it.
- Gene expression associations were specific to peripheral immune cell types and activation states.
- PLEKHA1 and TSTD1 were upregulated, and FIBP was downregulated in natural killer and T cells in AD brain tissue.
- Findings highlight potential targets for immune-based AD prevention and treatment.