Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway - PubMed
2 days ago
- #Osteoporosis
- #Autophagy
- #Betulinic acid
- Betulinic acid (BA) alleviates bone loss in osteoporosis (OP) by reducing oxidative stress and inflammation.
- BA suppresses NLRP3 inflammasome activation and inflammatory cytokine release in an ovariectomized rat model.
- In vitro, BA enhances autophagy in H2O2-treated osteoblasts via upregulation of LC3b II and Beclin-1.
- The protective effects of BA are mediated through the AMPK-mTOR signaling pathway, promoting osteogenic differentiation.
- BA's anti-inflammatory and antioxidant actions improve osteoblast function and mitigate OP-related bone damage.