ZIC2 affects oral squamous cell carcinoma stemness by regulating glycerophosphocholine metabolism via LYPLA2 - PubMed
7 hours ago
- #stemness
- #metabolism
- #oral cancer
- ZIC2 is a transcription factor highly expressed in oral squamous cell carcinoma (OSCC) and associated with poor prognosis.
- Knockdown of ZIC2 inhibits OSCC cell proliferation, migration, invasion, and spheroid formation, while overexpression has the opposite effect.
- ZIC2 regulates glycerophosphocholine (GPC) metabolism via LYPLA2, influencing OSCC stemness.
- GPC increases OSCC stemness, and ZIC2-mediated regulation of GPC affects cancer stem cell markers Nanog and OCT4.
- LYPLA2 overexpression rescues the effects of ZIC2 knockdown on OSCC cell behavior.
- ZIC2 is identified as a potential therapeutic target for OSCC, offering new treatment insights.