Ribonuclease 4 Functions in Nociceptor-Mediated Nerve Homeostasis - PubMed
8 hours ago
- #RNase4
- #nociceptor
- #neuropathic pain
- Ribonuclease 4 (RNase4) is selectively expressed in unmyelinated nociceptors.
- RNase4 has a cell-autonomous role in regulating nociceptor function, as shown in deficient mice and single-cell data.
- In a neuropathic pain model, RNase4 expression increases during pain and recovery, and its deletion affects mechanical sensation.
- RNase4 also non-cell-autonomously influences the myelin structure of nearby myelinated axons.
- The findings highlight RNase4 as a dual regulator of nociceptor biology and myelin integrity, linking it to pain regulation and nerve repair.