Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer - PubMed
5 hours ago
- #immune exclusion
- #FMR1-FTO axis
- #gastric cancer
- Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to immune exclusion in gastric cancer.
- CAFs form a collagen barrier via collagen-integrin interactions and MIF signaling, excluding CD8+ T cells from tumor cores.
- Elevated m6A regulator scores in tumor nests correlate with immune exclusion, reduced ICI responsiveness, and poor survival.
- FTO is highly expressed in immune-excluded tumors and linked to stromal activation and T-cell exclusion.
- FMR1 depletion reduces FTO protein abundance, suggesting a post-translational regulatory relationship.
- The FMR1-FTO axis is a potential therapeutic target to disrupt immune exclusion and improve immunotherapy sensitivity.