Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia - PubMed
8 days ago
- #tumor-immune-neural circuit
- #GDF15
- #cancer cachexia
- Cancer-induced cachexia and anorexia lack effective treatments due to unclear mechanisms.
- A tumor-immune-neural circuit involving GDF15 drives cachexia and anorexia in cancers.
- Macrophages, induced by tumor-derived CSF1, are a major source of GDF15.
- GDF15 acts via the central nervous system to enhance β-adrenergic signaling, worsening cachexia.
- Disrupting the GDF15-CSF1-RET loop with antibodies or inhibitors reduces cachexia and anorexia.
- The study highlights the tumor-immune-neural triad as a promising therapeutic target.