Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals - PubMed
14 hours ago
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- #gut-microbiome
- #antibiotics
- Antibiotic use is linked to long-term changes in gut microbiome composition.
- Study analyzed data from 14,979 individuals using Swedish Prescribed Drug Register and fecal metagenomes.
- Antibiotic use within the past year showed the greatest reduction in species diversity.
- Significant microbiome changes were also observed for antibiotic use 1-4 and 4-8 years prior.
- Clindamycin, fluoroquinolones, and flucloxacillin had the strongest associations with altered species abundance.
- Penicillin V, extended-spectrum penicillins, and nitrofurantoin showed minimal impact on species abundance.
- Even a single antibiotic course 4-8 years prior had lasting effects on the gut microbiome.
- Authors report various competing interests, including financial ties to pharmaceutical companies.
- Study funded by multiple Swedish research foundations, including the Swedish Heart-Lung Foundation and Swedish Research Council.