Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs) and Small Intestinal Submucosa (SIS) Hydrogel Composite Can Meliorate TNBS-Induced Experimental Colitis Through Regulating Inhibiting Macrophage Po
4 hours ago
- #Mesenchymal Stem Cells
- #Macrophage Polarization
- #Colitis Treatment
- BM-MSCs combined with SIS hydrogel improve experimental colitis by regulating macrophage polarization away from the M1 phenotype.
- The composite enhances RAW264.7 cell proliferation and inhibits M1 polarization and cytokine expression in vitro.
- In a TNBS-induced colitis mouse model, the treatment reduces disease severity and inflammatory cytokines like IL-1β and TNF-α.