Advances in the immunosuppression of porcine reproductive and respiratory syndrome virus - PubMed
5 hours ago
- #vaccine development
- #immunosuppression
- #PRRSV
- PRRS is a highly infectious disease caused by PRRSV, second only to ASFV in impact.
- Comprehensive studies have been conducted on PRRSV's genome, protein function, pathogenicity, and vaccines.
- Despite numerous vaccines, complete immune protection in pigs is lacking due to immune evasion and immunosuppression.
- Key immunosuppressive mechanisms include antigen escape, delayed neutralization antibody production, and T cell immunity issues.
- Other mechanisms involve antibody-dependent enhancement, dendritic cell function inhibition, and regulatory T cell induction.
- Understanding these mechanisms is crucial for PRRSV pathogenesis and vaccine development.