Anti-PLA2R antibodies promote endothelial pyroptosis and a procoagulant phenotype through FcγRI signaling - PubMed
3 days ago
- #endothelial pyroptosis
- #anti-PLA2R antibodies
- #thromboembolism
- Anti-PLA2R antibodies are elevated in membranous nephropathy patients with thromboembolism and correlate with coagulation markers.
- These antibodies induce a procoagulant state in endothelial cells by upregulating tissue factor and adhesion molecules via FcγRI signaling.
- FcγRI activation leads to NLRP3 inflammasome-mediated pyroptosis, releasing IL-1β and IL-18, which is inhibited by NLRP3 blockers.
- Complement anaphylatoxins C3a and C5a amplify the procoagulant response through their receptors, and antagonists can reverse these effects.
- Targeting FcγRI and inflammasome pathways may reduce thromboembolic risk in membranous nephropathy.