Why Do Most People Quit Ozempic After Two Years?
a year ago
- #weight-loss
- #GLP-1
- #obesity
- Weight-loss drugs like semaglutide (Wegovy) are popular but require indefinite use for sustained effectiveness.
- A JAMA study found most people quit these drugs within two years, leading to weight regain and loss of health benefits.
- GLP-1 receptor agonists (e.g., semaglutide, Ozempic) promote weight loss and improve cardiometabolic health but benefits reverse upon discontinuation.
- Set point theory suggests the body resists weight loss by increasing appetite and reducing calorie burn.
- Clinical trials show weight regain after stopping GLP-1 drugs, though some modest health benefits may persist.
- Insurance coverage and high costs ($1,000/month) are major barriers to continued use, especially for non-diabetic patients.
- Stigma around obesity and weight-loss drugs may influence discontinuation rates.
- Researchers are exploring dosage tapering to maintain weight loss without indefinite treatment.