ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progression - PubMed
5 hours ago
- #mTOR signaling
- #renal cell carcinoma
- #palmitoylation
- ZDHHC9 palmitoylates LAMTOR1 at Cys3/4 residues, enhancing mTORC1 recruitment and activating mTOR signaling in renal cell carcinoma (RCC).
- LAMTOR1 is a crucial regulator that recruits mTORC1 to lysosomes, influencing cell growth and cancer progression.
- The study highlights ZDHHC9 as a key mediator of RCC progression, suggesting its potential as a diagnostic and therapeutic target.
- Existing research indicates mTORC1 signaling contributes to RCC progression, but regulatory mechanisms remain unclear.
- The findings provide novel insights into RCC pathogenesis through the ZDHHC9-LAMTOR1-mTOR signaling axis.