PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells - PubMed
5 hours ago
- #PIEZO1
- #muscle regeneration
- #extracellular vesicles
- PIEZO1 channels are mechanically-activated ion channels expressed in many cell types.
- Pharmacological activation of PIEZO1 by Yoda1 promotes skeletal muscle regeneration by controlling myogenic precursor cell fate.
- Yoda1 treatment in myotubes significantly increases small extracellular vesicle (sEV) release and alters their proteomic cargo.
- sEVs released from both myoblasts and myotubes under PIEZO1 activation promote myotube formation, but through different mechanisms.
- Yoda1 increases PIEZO1 protein expression in vesicles from myotubes, suggesting different biogenesis in undifferentiated vs. differentiated cells.
- PIEZO1 is proposed as a key regulator of sEV release in myogenic precursors, impacting intercellular communication during muscle regeneration.