Associations of activities of daily living disability and instrumental activities of daily living disability with all-cause mortality: evidence from five major longitudinal studies - PubMed
3 days ago
- #Disability
- #Aging
- #Mortality
- ADL and IADL disabilities are linked to higher all-cause mortality in middle-aged and older adults across five longitudinal studies.
- Hazard ratios for mortality increased with disability severity: 1.44 for one ADL item, 2.14 for ≥2 ADL items; 1.59 for one IADL item, 2.41 for ≥2 IADL items.
- Chronic conditions and depression may mediate the association between disability and mortality, with depression showing consistent potential contributions across cohorts.
- Additive interaction between ADL and IADL disabilities was detected in CHARLS and MHAS, indicating combined effects on mortality risk.
- The hazard ratios for higher disability burden decreased over follow-up time in some cohorts, suggesting time-dependent effects.