Mouse Models of Diabetic Complications: Dissecting Molecular Mechanisms of Disease Progression - PubMed
6 hours ago
- #diabetic complications
- #mouse models
- #molecular mechanisms
- Diabetes mellitus causes chronic complications including nephropathy, neuropathy, and retinopathy.
- Molecular mechanisms like oxidative stress, inflammation, and mitochondrial dysfunction drive progression.
- Key pathways include NF-κB, TGF-β, PKC, AGE-RAGE axis, and Nrf2.
- Mouse models like STZ-induced, Akita, db/db, and BTBR ob/ob simulate distinct aspects of disease.
- Therapeutic strategies targeting conserved pathways show efficacy across models.