Biosensors for translatable GPCR bias - PubMed
5 hours ago
- #drug discovery
- #biased agonism
- #GPCR biosensors
- Biosensors provide advanced tools for studying GPCR biased agonism by capturing signaling events missed by traditional endpoint assays.
- They enable the resolution of multiple mechanistic layers, including receptor dynamics, G protein coupling, GTP formation, and β-arrestin engagement.
- Open platforms allow for comparative profiling, while more orthogonal systems enhance mechanistic attribution and physiological relevance.
- Recent advancements suggest that bias should be viewed as graded evidence rather than a binary label.
- The article discusses how biosensors help transform localized assay data into translatable pharmacological evidence for drug discovery.