Location-biased β-arrestin conformations direct GPCR signaling - PubMed
5 hours ago
- #β-arrestin
- #ERK signaling
- #GPCR
- β-arrestins regulate GPCR desensitization, internalization, and signaling.
- GPCRs can initiate distinct signaling cascades from various subcellular locations (location bias).
- Study used BRET biosensors and ERK reporters to investigate AT1R signaling.
- β-arrestin 1 and 2 adopted distinct conformations at different subcellular locations.
- Different β-arrestin conformations were linked to varied ERK activation profiles.
- Identified receptor-free, activated β-arrestins at the plasma membrane promoting ERK activation independently of G proteins.
- Findings highlight β-arrestins' roles beyond traditional G protein pathways.