Effectiveness of Non-Antibiotic Therapies in the Management of Recurrent Urinary Tract Infections in Women: A Systematic Review - PubMed
3 days ago
- #Recurrent UTI
- #Non-Antibiotic Therapy
- #Systematic Review
- Systematic review evaluates non-antibiotic therapies for recurrent urinary tract infections (rUTIs) in women due to rising antimicrobial resistance.
- Methenamine hippurate and vaginal estrogen (for postmenopausal women) are supported by level 1 evidence as first-line non-antibiotic alternatives.
- Immunoprophylaxis with MV140 sublingual vaccine significantly reduces recurrence, with 56-58% of women remaining UTI-free in a large RCT.
- D-mannose shows mixed efficacy, effective in specialist settings but not in broad primary care, while cranberry products prevent resistant flora development.
- Probiotics significantly prolong the time to first recurrence, offering safe and effective alternatives to long-term antibiotics.