Transcription factor codes patterning neuronal groundplans of the cerebrum - PubMed
2 hours ago
- #neuronal patterning
- #transcription factors
- #cerebrum circuits
- Researchers developed methods in Drosophila melanogaster to embed neurons regulating mating into transcriptional contexts of neuronal lineages.
- Transcription factors expressed in complex combinations delineate cerebral hemilineages, which are classes of postmitotic neurons from the same stem cell.
- Hemilineages form major anatomical classes in the cerebrum, and these transcription factors are essential for generating their gross features.
- Subtypes of the same hemilineage can provide a common computational module for circuits regulating different drives.
- An orthogonal set of transcription factors stratifies hemilineage subtypes based on birth order.
- Findings suggest a hierarchical system of transcription factors builds, diversifies, and sexually differentiates lineally related neurons in motivated behavior circuits.
- The study links developmental patterning to transcriptional axes for gross vs. fine aspects of information flow, offering a framework for cerebral control of diverse drives.