ATP-binding cassette subfamily A member 5 suppresses pancreatic ductal adenocarcinoma progression and chemoresistance by promoting β-catenin ubiquitin-dependent degradation - PubMed
6 hours ago
- #Pancreatic Cancer
- #WNT Pathway
- #ABCA5
- ABCA5 acts as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC).
- Low ABCA5 expression correlates with poorer prognosis in PDAC patients.
- Overexpression of ABCA5 suppresses tumor growth, metastasis, and gemcitabine resistance.
- ABCA5 promotes β-catenin degradation by interacting with BTRC, inhibiting the WNT pathway.
- Combining ABCA5 overexpression with gemcitabine and PRI-724 enhances treatment efficacy.