The Impact of Exogenous Vitamin D on Pituitary Effects of Metformin in Postmenopausal Women with Subclinical Hypothyroidism and Normal Vitamin D Status: A Pilot Study - PubMed
4 hours ago
- #metformin
- #postmenopausal women
- #vitamin D
- Study investigates the impact of exogenous vitamin D on the pituitary effects of metformin in postmenopausal women with subclinical hypothyroidism and normal vitamin D status.
- Participants were divided into two groups: one treated with metformin/vitamin D combination therapy and the other with metformin alone.
- Results showed that combination therapy led to increased 25-hydroxyvitamin D levels and more pronounced improvements in glucose homeostasis markers, TSH, and FSH levels compared to metformin alone.
- Combination therapy also reduced LH and prolactin levels, which was not observed with metformin alone.
- Vitamin D monotherapy increased plasma 25-hydroxyvitamin D concentrations and modestly improved insulin sensitivity.
- The study concludes that exogenous vitamin D enhances the pituitary effects of metformin in the studied population.