Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain - PubMed
3 days ago
- #Parkinson's disease
- #α-synuclein
- #live imaging
- Genetically encoded fluorescent reporters developed to visualize α-synuclein (α-Syn) pathology in live brain.
- Reporters show a 5-fold fluorescence increase upon incorporation into α-Syn inclusions.
- Enables tracking of α-Syn inclusion propagation in awake mice cortex.
- Combined with Ca2+ imaging and whole-cell recording to measure pathological effects on neuronal activity and synaptic function.
- Targetable to specific neuronal subtypes for single-cell transcriptome and metabolome analysis.
- Used in live-cell imaging to identify inhibitors of α-Syn inclusion formation.
- Supports diverse applications for studying α-Syn inclusions in live brain.