Chromatin-binding protein HMGN1 promotes HCC tumorigenesis via histone methylation-induced RALB transcriptional suppression - PubMed
5 hours ago
- #epigenetics
- #HMGN1
- #Hepatocellular carcinoma
- HMGN1, a chromatin-binding protein, is upregulated in HCC tissues and linked to advanced disease and poor prognosis.
- HMGN1 promotes HCC metastasis by binding to the RALB gene promoter and recruiting the repressive histone mark H3K9me2 to silence RALB transcription.
- A nanoparticle delivery system with siRNA against HMGN1 effectively inhibits metastasis in orthotopic liver xenograft models.
- HMGN1 is identified as a key epigenetic driver of HCC metastasis, with siRNA-nanoparticle targeting proposed as a potential therapeutic strategy.