Comparative adverse event reporting patterns of desogestrel versus norethisterone in third-generation combined oral contraceptives: A disproportionality analysis of the FAERS satabase - PubMed
4 hours ago
- #adverse events
- #FAERS database
- #oral contraceptives
- Analysis of adverse event reporting patterns for desogestrel (DES) and norethisterone (NOR) in third-generation combined oral contraceptives using FAERS data.
- DES showed stronger signals for arterial thrombosis, perinatal complications, and abnormal withdrawal bleeding.
- NOR was more associated with vena cava thrombosis, contraceptive failure, withdrawal bleeding, and breast enlargement.
- Subgroup analysis highlighted higher signal strength in women aged 18 to 40 years across reproductive, pregnancy, and vascular disorders.
- Clinicians are advised to pay particular attention to reproductive-age women when prescribing these contraceptives.